Structure of PDB 4mtl Chain A

Receptor sequence
>4mtlA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
KFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYLEEHA
EELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKN
TLQCTAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLL
TTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKL
FKGILKWD
3D structure
PDB4mtl Human Methyltransferase-Like Protein 21C
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 SAH A G88 V91 W92 A95 G120 G122 D141 L142 V171 W172 S193 D194 Y197 F201 G32 V35 W36 A39 G64 G66 D85 L86 V115 W116 S137 D138 Y141 F145
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016279 protein-lysine N-methyltransferase activity
GO:0031072 heat shock protein binding
Biological Process
GO:0006479 protein methylation
GO:0007519 skeletal muscle tissue development
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0018022 peptidyl-lysine methylation
GO:0032259 methylation
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:4mtl, PDBe:4mtl, PDBj:4mtl
PDBsum4mtl
PubMed
UniProtQ5VZV1|MT21C_HUMAN Protein-lysine methyltransferase METTL21C (Gene Name=METTL21C)

[Back to BioLiP]