Structure of PDB 4msx Chain A

Receptor sequence
>4msxA (length=395) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
YAYLETVVREKLDFDSEKICCITLSPLNVYCCLVCGHYYQGRHEKSPAFI
HSIDENHHVFLNLTSLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPK
DLEDFPRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRDHF
LLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLN
PIDPRLFLLWLFNKICSSSNDLKSILNHSCKGKVKIAKSESVTGKVIVKP
FWVLTLDLPEFSPFEDGNSVDDLPQINITKLLTKFTKTVFELTRLPQFLI
FHFNRFDRNSDHPVKNRNQTLVEFSSELEILHVKYRLKANVVHVVIGDEK
SHWITQLYDNKSEKWIEIDGINTTEREAELLFLKETFIQVWEKQE
3D structure
PDB4msx The crystal structure of S. cerevisiae Sad1, a catalytically inactive deubiquitinase that is broadly required for pre-mRNA splicing.
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C60 C63 H79 H85 C32 C35 H51 H57
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016579 protein deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4msx, PDBe:4msx, PDBj:4msx
PDBsum4msx
PubMed24681967
UniProtP43589|SAD1_YEAST Pre-mRNA-splicing factor SAD1 (Gene Name=SAD1)

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