Structure of PDB 4msl Chain A

Receptor sequence
>4mslA (length=654) Species: 9606 (Homo sapiens) [Search protein sequence]
CGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVGQS
KLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGS
RGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVS
KNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDL
GKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQL
PSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDR
HLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRK
PENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHG
SVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSR
PINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTEST
SQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLR
LRKSSMCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPEL
KGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNF
LSPE
3D structure
PDB4msl Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2ET A Y271 S283 R292 F317 Y318 Y212 S224 R233 F258 Y259 PDBbind-CN: -logKd/Ki=6.15,Kd=0.70uM
BindingDB: IC50=4000nM
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:4msl, PDBe:4msl, PDBj:4msl
PDBsum4msl
PubMed24531479
UniProtQ99523|SORT_HUMAN Sortilin (Gene Name=SORT1)

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