Structure of PDB 4ms4 Chain A

Receptor sequence
>4ms4A (length=408) Species: 9606 (Homo sapiens) [Search protein sequence]
RRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHH
DSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLS
YGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTT
EVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLF
YETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMT
EAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQE
APLAYDAIWALALALNKTSRLEDFNYNNQTITDQIYRAMNSSSFEGVSGH
VVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPP
ADDYKDDD
3D structure
PDB4ms4 Structural mechanism of ligand activation in human GABA(B) receptor.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2C0 A W65 C129 S130 G151 S153 H170 F249 Y250 I276 W278 E349 W16 C80 S81 G102 S104 H121 F200 Y201 I227 W229 E300 BindingDB: EC50=1000nM,IC50=15nM,Ki=6000nM
Gene Ontology
Molecular Function
GO:0004965 G protein-coupled GABA receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ms4, PDBe:4ms4, PDBj:4ms4
PDBsum4ms4
PubMed24305054
UniProtQ9UBS5|GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (Gene Name=GABBR1)

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