Structure of PDB 4mrs Chain A

Receptor sequence

>4mrsA (length=600) Species: 279238 (Novosphingobium aromaticivorans DSM 12444)

NPKDARHDGWQTLKRFLPYLWPADNAVLRRRVVGAILMVLLGKATTLALP
FAYKKAVDAMTLGGGAQPALTVALAFVLAYALGRFSGVLFDNLRNIVFER
VGQDATRHLAENVFARLHKLSLRFHLARRTGEVTKVIERGTKSIDTMLYF
LLFNIAPTVIELTAVIVIFWLNFGLGLVTATILAVIAYVWTTRTITEWRT
HLREKMNRLDGQALARAVDSLLNYETVKYFGAESREEARYASAARAYADA
AVKSENSLGLLNIAQALIVNLLMAGAMAWTVYGWSQGKLTVGDLVFVNTY
LTQLFRPLDMLGMVYRTIRQGLIDMAEMFRLIDTHIEVADVPNAPALVVN
RPSVTFDNVVFGYDRDREILHGLSFEVAAGSRVAIVGPSGAGKSTIARLL
FRFYDPWEGRILIDGQDIAHVTQTSLRAALGIVPQDSVLFNDTIGYNIAY
GRDGASRAEVDAAAKGAAIADFIARLPQGYDTEVGERGLKLSGGEKQRVA
IARTLVKNPPILLFDEATSALDTRTEQDILSTMRAVASHRTTISIAHRLS
TIADSDTILVLDQGRLAEQGSHLDLLRRDGLYAEMWARQAAESAEVSEAA

3D structure

• PDB: 4mrs Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.
• Chain: A
• Resolution: 2.35 Å

Enzymatic activity

• Enzyme Commision number: 7.-.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDS	A	K149 R206 R210	K142 R199 R203
BS02	PO4	A	S396 G399 S401	S389 G392 S394
BS03	GDS	A	Y156 L268 N269 Q272 D316 M317 G319 M320	Y149 L261 N262 Q265 D309 M310 G312 M313

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0042626 ATPase-coupled transmembrane transporter activity
• GO:0140359 ABC-type transporter activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0046689 response to mercury ion
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:4mrs, PDBe:4mrs, PDBj:4mrs
• PDBsum: 4mrs
• PubMed: 24604198
• UniProt: Q2G506|ATM1_NOVAD ATM1-type heavy metal exporter (Gene Name=atm1)