Structure of PDB 4mr3 Chain A

Receptor sequence
>4mr3A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4mr3 RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1K0 A W81 P82 Q85 V87 L92 N140 I146 W40 P41 Q44 V46 L51 N99 I105 PDBbind-CN: -logKd/Ki=5.94,Kd=1142nM
BindingDB: IC50=510nM,Kd=1100nM
External links
PDB RCSB:4mr3, PDBe:4mr3, PDBj:4mr3
PDBsum4mr3
PubMed24248379
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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