Structure of PDB 4mq4 Chain A

Receptor sequence
>4mq4A (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
APGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFA
TGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQE
EPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLG
AGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGA
LEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGV
DDVKGVFFAWAQKV
3D structure
PDB4mq4 To be Published
ChainA
Resolution2.2042 Å
3D
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Enzymatic activity
Enzyme Commision number 2.1.1.28: phenylethanolamine N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2D5 A Y27 Y35 Y40 V53 K57 D101 F102 L103 N106 D158 V159 F182 C183 V187 E219 Y222 M258 Y11 Y19 Y24 V37 K41 D85 F86 L87 N90 D142 V143 F166 C167 V171 E203 Y206 M242
Gene Ontology
Molecular Function
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:4mq4, PDBe:4mq4, PDBj:4mq4
PDBsum4mq4
PubMed
UniProtP11086|PNMT_HUMAN Phenylethanolamine N-methyltransferase (Gene Name=PNMT)

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