Structure of PDB 4mpm Chain A

Receptor sequence
>4mpmA (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
RPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSP
EDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVK
LSSFSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWD
3D structure
PDB4mpm The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity.
ChainA
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.7.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A F42 N45 H64 V68 V71 L92 K95 H96 V99 V101 S105 F106 V109 F40 N43 H62 V66 V69 L90 K93 H94 V97 V99 S103 F104 V107
Gene Ontology
Molecular Function
GO:0005092 GDP-dissociation inhibitor activity
GO:0005344 oxygen carrier activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0098809 nitrite reductase activity
Biological Process
GO:0001666 response to hypoxia
GO:0015671 oxygen transport
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4mpm, PDBe:4mpm, PDBj:4mpm
PDBsum4mpm
PubMed24699645
UniProtQ9NPG2|NGB_HUMAN Neuroglobin (Gene Name=NGB)

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