Structure of PDB 4mot Chain A

Receptor sequence
>4motA (length=193) Species: 171101 (Streptococcus pneumoniae R6) [Search protein sequence]
QVLEGLDAVRKRPGMYIGSTDGAGLHHLVWEIVDNAVDEALSGFGDRIDV
TINKDGSLTVQDHGRGMPTGMHAMGIPTVEVIFTILHAVGSSVVNALSSW
LEVEITRDGAVYKQRFENGGKPVTTLKKIGTALKSKTGTKVTFMPDATIF
STTDFKYNTISERLNESAFLLKNVTLSLTDKRTDEAIEFHYEN
3D structure
PDB4mot Thiazolopyridone ureas as DNA gyrase B inhibitors: Optimization of antitubercular activity and efficacy.
ChainA
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2B7 A I48 N51 A52 E55 V76 D78 R81 G82 M83 P84 I98 R140 T172 I32 N35 A36 E39 V60 D62 R65 G66 M67 P68 I82 R107 T139 PDBbind-CN: -logKd/Ki=7.30,IC50=50nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006265 DNA topological change

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4mot, PDBe:4mot, PDBj:4mot
PDBsum4mot
PubMed24405701
UniProtQ8DQB5

[Back to BioLiP]