Structure of PDB 4moq Chain A

Receptor sequence

>4moqA (length=569) Species: 230624 (Trametes ochracea)

KYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEIDSGLKIGAHKKNTVE
YQKNIDKFVNVIQGQLMSVSVPVNTLVVDTLSPTSWQASTFFVRNGSNPE
QDPLRNLSGQAVTRVVGGMSTHWTCATPRFDREQRPLLVKDDADADDAEW
DRLYTKAESYFQTGTDQFKESIRHNLVLNKLTEEYKGQRDFQQIPLAATR
RSPTFVEWSSANTVFDLQNRPNTDAPEERFNLFPAVACERVVRNALNSEI
ESLHIHDLISGDRFEIKADVYVLTAGAVHNTQLLVNSGFGQLGRPNPANP
PELLPSLGSYITEQSLVFCQTVMSTELIDSVKSDMTIRGTPGELTYSVTY
TPGASTNKHPDWWNEKVKNHMMQHQEDPLPIPFEDPEPQVTTLFQPSHPW
HTQIHRDAFSYQSIDSRLIVDWRFFGRTEPKEENKLWFSDKITDAYNMPQ
PTFDFRFPAGRTSKEAEDMMTDMCVMSAKIGGFLPGSLPQFMEPGLCLHL
GGTHRMGFDEKEDNCCVNTDSRVFGFKNLFLGGCGNIPTAYGANPTLTAM
SLAIKSCEYIKQNFTPSPF

3D structure

• PDB: 4moq Structural Basis for Binding of Fluorinated Glucose and Galactose to Trametes multicolor Pyranose 2-Oxidase Variants with Improved Galactose Conversion.
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 1.1.3.10: pyranose oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FDA	A	V52 G55 P56 I57 D76 I77 T158 G163 M164 H167 W168 T169 A171 C283 A320 H324 L547 N593 T595	V7 G10 P11 I12 D31 I32 T113 G118 M119 H122 W123 T124 A126 C238 A275 H279 L498 N544 T546
BS02	2FG	A	Q448 D452 R472 L545 C546 H548 N593	Q403 D407 R423 L496 C497 H499 N544
BS03	2FG	A	G398 A399 H404 P405	G353 A354 H359 P360

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
• GO:0050233 pyranose oxidase activity
• GO:0050660 flavin adenine dinucleotide binding

Cellular Component

• GO:0042597 periplasmic space

External links

• PDB: RCSB:4moq, PDBe:4moq, PDBj:4moq
• PDBsum: 4moq
• PubMed: 24466218
• UniProt: Q7ZA32