Structure of PDB 4mmi Chain A

Receptor sequence
>4mmiA (length=636) Species: 984 (Pedobacter heparinus) [Search protein sequence]
VTRKDFDHINLEYSGLEKVNKAVAAGNYDDAAKALLAYYREKSKAREPDF
SNAEKPADIRQPIDKVTREMADKALVHQFQPHKGYGYFDYGKDINWQMWP
VKDNEVRWQLHRVKWWQAMALVYHATGDEKYAREWVYQYSDWARKNPLGL
SQDNDKFVWRPLEVSDRVQSLPPTFSLFVNSPAFTPAFLMEFLNSYHQQA
DYLSTHYAEQGNHRLFEAQRNLFAGVSFPEFKDSPRWRQTGISVLNTEIK
KQVYADGMQFELSPIYHVAAIDIFLKAYGSAKRVNLEKEFPQSYVQTVEN
MIMALISISLPDYNTPMFGDSWITDKNFRMAQFASWARVFPANQAIKYFA
TDGKQGKAPNFLSKALSNAGFYTFRSGWDKNATVMVLKASPPGEFHAQPD
NGTFELFIKGRNFTPDAGVFVYSGDEAIMKLRNWYRQTRIHSTLTLDNQN
MVITKARQNKWETGNNLDVLTYTNPSYPNLDHQRSVLFINKKYFLVIDRA
IGEATGNLGVHWQLKEDSNPVFDKTKNRVYTTYRDGNNLMIQSLNADRTS
LNEEEGKVSYVYNKELKRPAFVFEKPKKNAGTQNFVSIVYPYDGQKAPEI
SIRENKGNDFEKGKLNLTLTINGKQQLVSVPLEHHH
3D structure
PDB4mmi Crystal Structure of Pedobacter heparinus Heparin Lyase Hep III with the Active Site in a Deep Cleft
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.2.8: heparin-sulfate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A H241 E245 H213 E217
BS02 CA A Q426 D444 H469 Q398 D416 H441
Gene Ontology
Molecular Function
GO:0015021 heparin-sulfate lyase activity
GO:0016829 lyase activity
Biological Process
GO:0030200 heparan sulfate proteoglycan catabolic process
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mmi, PDBe:4mmi, PDBj:4mmi
PDBsum4mmi
PubMed24437462
UniProtQ59289|HEPC_PEDHD Heparin-sulfate lyase (Gene Name=hepC)

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