Structure of PDB 4mme Chain A

Receptor sequence
>4mmeA (length=504) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
AIYYVYIESWTLGFAIKFLVGLVPEPPTDPDSILRPFKEFLYSYIGVPKG
DEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAV
FLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGL
GFGAIITFASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFFG
VANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSI
AGMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWA
GTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITP
AFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERR
RNHE
3D structure
PDB4mme Structural basis for action by diverse antidepressants on biogenic amine transporters.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 Y21 V23 D24 A351 T354 S355 G16 Y17 V19 D20 A344 T347 S348
BS02 NA A A22 V23 D24 N27 S254 N286 A18 V19 D20 N23 S247 N279
BS03 29Q A Y21 A22 D24 V104 A105 Y108 F253 G256 F259 S355 G359 Y17 A18 D20 V100 A101 Y104 F246 G249 F252 S348 G352 MOAD: Kd=318nM
PDBbind-CN: -logKd/Ki=6.50,Kd=318nM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4mme, PDBe:4mme, PDBj:4mme
PDBsum4mme
PubMed24121440
UniProtO67854

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