Structure of PDB 4mma Chain A

Receptor sequence
>4mmaA (length=504) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
ASYYVYIESWTLGFAIKFLVGLVPEPPTDPDSILRPFKEFLYSYIGVPKG
DEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAV
FLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGL
GFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFG
VANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSI
AGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWA
TGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITP
AFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAERR
RNHE
3D structure
PDB4mma Structural basis for action by diverse antidepressants on biogenic amine transporters.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 Y21 V23 A351 T354 S355 G16 Y17 V19 A344 T347 S348
BS02 NA A A22 D24 N27 S254 N286 A18 D20 N23 S247 N279
BS03 CXX A Y21 D24 P101 V104 A105 Y108 F259 S355 S356 G359 T408 Y17 D20 P97 V100 A101 Y104 F252 S348 S349 G352 T401 PDBbind-CN: -logKd/Ki=6.04,Ki=920nM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:4mma, PDBe:4mma, PDBj:4mma
PDBsum4mma
PubMed24121440
UniProtO67854

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