Structure of PDB 4mm8 Chain A

Receptor sequence
>4mm8A (length=498) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]
REHWATRLGLILAMAGYAVDLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
ASYYVYIESWTLGFAIKFLVGLVPEPPTDPDSILRPFKEFLYSYIGVPKG
DEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILAV
FLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFSLGL
GFGVLITFASYVRKDQDIVLSGLTAATLNEKASVILGGSISIPAAVAFFG
VANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSSI
AGMQGMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFWA
TGIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYITP
AFLAVLLVVWAREYITHWTVWITRFYIIGLFLFLTFLVFLAERRRNHE
3D structure
PDB4mm8 Structural basis for action by diverse antidepressants on biogenic amine transporters.
ChainA
Resolution3.31 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A G20 Y21 V23 D24 A351 G352 T354 S355 G16 Y17 V19 D20 A344 G345 T347 S348
BS02 NA A A22 V23 N27 S254 N286 A18 V19 N23 S247 N279
BS03 RFX A Y21 A22 D24 V104 A105 Y108 F253 G256 F259 G359 T408 Y17 A18 D20 V100 A101 Y104 F246 G249 F252 G352 T401 PDBbind-CN: -logKd/Ki=6.11,Ki=778nM
Gene Ontology
Biological Process
GO:0035725 sodium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4mm8, PDBe:4mm8, PDBj:4mm8
PDBsum4mm8
PubMed24121440
UniProtO67854

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