Structure of PDB 4mlp Chain A

Receptor sequence
>4mlpA (length=492) Species: 10090 (Mus musculus) [Search protein sequence]
ASSVHWFRKGLRLHDNPALLAAVRGARCVRCVYILDPWFAASSSVGINRW
RFLLQSLEDLDTSLRKLNSRLFVVRGQPADVFPRLFKEWGVTRLTFEYDS
EPFGKERDAAIMKMAKEAGVEVVTENSHTLYDLDRIIELNGQKPPLTYKR
FQALISRMELPKKPAVAVSSQQMESCRAEIQENHDDTYGVPSLEELGFPT
EGLGPAVWQGGETEALARLDKHLERKAWVANYERPRMNANSLLASPTGLS
PYLRFGCLSCRLFYYRLWDLYKKVKRNSTPPLSLFGQLLWREFFYTAATN
NPRFDRMEGNPICIQIPWDRNPEALAKWAEGKTGFPWIDAIMTQLRQEGW
IHHLARHAVACFLTRGDLWVSWESGVRVFDELLLDADFSVNAGSWMWLSC
SAFFQQFFHCYCPVGFGRRTDPSGDYIRRYLPKLKGFPSRYIYEPWNAPE
SVQKAAKCIIGVDYPRPIVNHAETSRLNIERMKQIYQQLSRY
3D structure
PDB4mlp Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase.
ChainA
Resolution1.943 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q307 W310 W338 H373 W392 W415
Catalytic site (residue number reindexed from 1) Q287 W290 W318 H353 W372 W395
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2CX A W310 H373 R376 H377 F399 V410 S414 W415 W417 W290 H353 R356 H357 F379 V390 S394 W395 W397
External links
PDB RCSB:4mlp, PDBe:4mlp, PDBj:4mlp
PDBsum4mlp
PubMed24080726
UniProtQ9R194|CRY2_MOUSE Cryptochrome-2 (Gene Name=Cry2)

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