Structure of PDB 4ml5 Chain A

Receptor sequence
>4ml5A (length=174) Species: 8400 (Aquarana catesbeiana) [Search protein sequence]
VSQVRQNYHSDCEAAVNRMLNLELYASYTYSSMYAFFDRDDVALHNVAEF
FKEQSHEEREHAEKFMKYQNKRGGRVVLQDIKKPERDEWGNTLEAMQAAL
QLEKTVNQALLDLHKLATDKVDPHLCDFLESEYLEEQVKDIKRIGDFITN
LKRLGLPENGMGEYLFDKHSVKES
3D structure
PDB4ml5 Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.
ChainA
Resolution1.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.16.3.1: ferroxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A E23 E58 H61 E23 E58 H61
BS02 FE2 A E136 D140 E136 D140
BS03 FE2 A E53 E57 E53 E57
BS04 FE2 A Q54 E103 D140 Q54 E103 D140
Gene Ontology
Molecular Function
GO:0004322 ferroxidase activity
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006826 iron ion transport
GO:0006879 intracellular iron ion homeostasis
GO:0006880 intracellular sequestering of iron ion
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:4ml5, PDBe:4ml5, PDBj:4ml5
PDBsum4ml5
PubMed25849404
UniProtP07798|FRI2_AQUCT Ferritin, middle subunit

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