Structure of PDB 4mk5 Chain A

Receptor sequence

>4mk5A (length=200) Species: 985958 (Influenza A virus (A/Lima/WRAIR1695P/2009(H1N1)))

GPLGSMEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFAAICTHLEVC
FMYSDFHFIDERGESIIVESGDPNALLKHRFEIIEGRDRIMAWTVVNSIC
NTTGVEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHI
HIFSFTGEEMATKADYTLDEESRARIKTRLFTIRQEMASRSLWDSFRQSE

3D structure

• PDB: 4mk5 Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	H41 D108 E119 I120 K134	H46 D113 E124 I125 K139
BS02	MN	A	E80 D108	E85 D113
BS03	28A	A	Y24 K34 I38 H41 E80 D108 E119 K134	Y29 K39 I43 H46 E85 D113 E124 K139	MOAD: ic50=0.45uM PDBbind-CN: -logKd/Ki=6.35,IC50=0.45uM

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:4mk5, PDBe:4mk5, PDBj:4mk5
• PDBsum: 4mk5
• PubMed: 23978130
• UniProt: M9V5A4