Structure of PDB 4mhn Chain A

Receptor sequence
>4mhnA (length=326) Species: 6945 (Ixodes scapularis) [Search protein sequence]
LKWPRDLRPLAHHDLLYMGQISEEDRGDFNATLRNFLVPRVVGSQKHREV
REFIVRSLKDLDWDVEEDCFDGQTPHGIKPFCNVIATLNPSACHRLVLAC
HYDSLLHKEGTFIGATDSAVPCAQLLYLARSLNGKLQNQKTRGDGLTLQL
VFFDGEEAFERWSSHDSLYGSRHLAQKWHEDRTSAERLESCLERSEIANQ
IDRMEVMVLLDLLGAENPRFYSYFGETQPVYRRLVNIESRLNDAGLMELP
RRRRRTNYFSNSSTVGFIEDDHIPFLKRSVPIVHIIPSPFPDVWHTLDDN
EQNLHHPTISNLNKIFKAFVSEYLQL
3D structure
PDB4mhn Structural and functional analyses of a glutaminyl cyclase from Ixodes scapularis reveal metal-independent catalysis and inhibitor binding.
ChainA
Resolution1.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.5: glutaminyl-peptide cyclotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D144 E184 H322 D117 E157 H295
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4mhn, PDBe:4mhn, PDBj:4mhn
PDBsum4mhn
PubMed24598748
UniProtB7QK46|QPCT_IXOSC Glutaminyl-peptide cyclotransferase (Gene Name=Qptc)

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