Structure of PDB 4mh7 Chain A

Receptor sequence
>4mh7A (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTAACMKD
FSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPK
HIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFP
VKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYL
LHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
3D structure
PDB4mh7 Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis.
ChainA
Resolution2.51 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N728 D741 N135 D148
BS02 MH7 A G594 A617 F673 M674 K675 A740 G18 A41 F80 M81 K82 A147 PDBbind-CN: -logKd/Ki=5.23,IC50=5.9uM
BindingDB: IC50=5900nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mh7, PDBe:4mh7, PDBj:4mh7
PDBsum4mh7
PubMed24219778
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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