Structure of PDB 4mgd Chain A

Receptor sequence
>4mgdA (length=241) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB4mgd Structural and functional profiling of environmental ligands for estrogen receptors.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 D538 E542 I54 K58 L68 V72 D230 E234
BS02 27N A T347 A350 E353 L387 F404 M421 T43 A46 E49 L83 F100 M115 PDBbind-CN: -logKd/Ki=4.69,Kd=20.19uM
BindingDB: EC50=31nM,IC50=43nM
External links
PDB RCSB:4mgd, PDBe:4mgd, PDBj:4mgd
PDBsum4mgd
PubMed25260197
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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