Structure of PDB 4mg6 Chain A

Receptor sequence
>4mg6A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
FTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB4mg6 Structural and functional profiling of environmental ligands for estrogen receptors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 D538 L539 E542 I54 K58 L68 V72 E76 D225 L226 E229
BS02 27G A L346 L349 A350 E353 M388 F404 M421 I424 L428 L42 L45 A46 E49 M84 F100 M111 I114 L118 PDBbind-CN: -logKd/Ki=5.62,Kd=2.42uM
External links
PDB RCSB:4mg6, PDBe:4mg6, PDBj:4mg6
PDBsum4mg6
PubMed25260197
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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