Structure of PDB 4mfp Chain A

Receptor sequence
>4mfpA (length=323) Species: 1867 (Actinoplanes teichomyceticus) [Search protein sequence]
MDPETVRIALGLEERTAAWLTELDELGPPAEPVRLPRGEEARDLLRRLEV
PELDAEEIVAAAPDPDRDPALWWLLERTHHAIVRHMGDHRAKPRGGPPLP
YEGGAAARYFHVYVFLATVPAVRRFHAERGIPDEVGWETLTQLGELVAIH
RRKYGQGGMNMQWWTTYHLRGILYRLGRLQFSLATGKDGTPHLGLAVPEW
GGPLLPKAYDESLHRARPFFDRHFPEHGARVAWGSSWMLDPQLEEYLTED
SNIIQLARFWTLTDSAPEPGNADGDSSILEFVFRYNGQPLDELPQRSSLE
RAVIAHLKAGRHWHMRTGFVKLP
3D structure
PDB4mfp Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus
ChainA
Resolution2.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K92 P93 W163 Y167 S276 F281 K92 P93 W163 Y167 S276 F281
BS02 COA A V197 P203 L204 S236 W237 S251 N252 I253 F281 S297 S298 L299 V197 P203 L204 S236 W237 S251 N252 I253 F281 S297 S298 L299
BS03 GCS A W163 W164 F281 W163 W164 F281
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4mfp, PDBe:4mfp, PDBj:4mfp
PDBsum4mfp
PubMed25095906
UniProtQ70AY4

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