Structure of PDB 4mf3 Chain A

Receptor sequence
>4mf3A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
SLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGF
IYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVI
DFSKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKS
KISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQ
RNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEK
WWRGNGCP
3D structure
PDB4mf3 GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SXI A Y62 P89 L90 T91 R96 T143 M190 E191 S194 Y217 Y62 P89 L90 T91 R96 T143 M190 E191 S194 Y217
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4mf3, PDBe:4mf3, PDBj:4mf3
PDBsum4mf3
PubMed24140446
UniProtP39086|GRIK1_HUMAN Glutamate receptor ionotropic, kainate 1 (Gene Name=GRIK1)

[Back to BioLiP]