Structure of PDB 4meq Chain A

Receptor sequence
>4meqA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4meq Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
ChainA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25O A W81 P82 F83 V87 L92 N140 I146 W40 P41 F42 V46 L51 N99 I105 PDBbind-CN: -logKd/Ki=3.60,IC50=250uM
External links
PDB RCSB:4meq, PDBe:4meq, PDBj:4meq
PDBsum4meq
PubMed24090311
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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