Structure of PDB 4meo Chain A

Receptor sequence
>4meoA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4meo Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25V A W81 P82 Q85 V87 D88 L92 L94 N140 I146 W40 P41 Q44 V46 D47 L51 L53 N99 I105 PDBbind-CN: -logKd/Ki=3.60,IC50=250uM
BindingDB: IC50=42000nM
External links
PDB RCSB:4meo, PDBe:4meo, PDBj:4meo
PDBsum4meo
PubMed24090311
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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