Structure of PDB 4men Chain A

Receptor sequence
>4menA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4men Discovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual Screening.
ChainA
Resolution1.81 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 25K A W81 P82 F83 L92 L94 N140 W40 P41 F42 L51 L53 N99 PDBbind-CN: -logKd/Ki=3.90,IC50=125uM
External links
PDB RCSB:4men, PDBe:4men, PDBj:4men
PDBsum4men
PubMed24090311
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]