Structure of PDB 4mdq Chain A

Receptor sequence
>4mdqA (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVV
3D structure
PDB4mdq Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
ChainA
Resolution2.119 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 28W A L54 G58 F91 V93 H96 L30 G34 F67 V69 H72 MOAD: Ki=1.2uM
PDBbind-CN: -logKd/Ki=5.92,Ki=1.2uM
BindingDB: Ki=1200nM
BS02 28W A M50 K51 R97 Y100 M26 K27 R73 Y76 MOAD: Ki=1.2uM
PDBbind-CN: -logKd/Ki=5.92,Ki=1.2uM
BindingDB: Ki=1200nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:4mdq, PDBe:4mdq, PDBj:4mdq
PDBsum4mdq
PubMed24207125
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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