Structure of PDB 4mdk Chain A

Receptor sequence
>4mdkA (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVAIFGPPNTYYEGG
YFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPSERWNP
TQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDREYTDIIR
KQVLGTKVDAERDGVKVP
3D structure
PDB4mdk E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
ChainA
Resolution2.6095 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C93
Catalytic site (residue number reindexed from 1) C87
Enzyme Commision number 2.3.2.23: E2 ubiquitin-conjugating enzyme.
2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U94 A P48 T51 Y52 Y53 F58 L131 N132 W151 Y161 P42 T45 Y46 Y47 F52 L115 N116 W135 Y145
External links
PDB RCSB:4mdk, PDBe:4mdk, PDBj:4mdk
PDBsum4mdk
PubMed24316736
UniProtP49427|UB2R1_HUMAN Ubiquitin-conjugating enzyme E2 R1 (Gene Name=CDC34)

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