Structure of PDB 4mdd Chain A

Receptor sequence
>4mddA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
PTLVSALETIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAK
AIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFAPDLII
NEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDG
LKSQALFDAIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEVV
ENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB4mdd Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V571 V575 K579 L589 M593 W600 N759 V42 V46 K50 L60 M64 W71 N230
BS02 29M A M560 L563 N564 G567 Q570 M601 M604 A605 F623 M639 C736 T739 M31 L34 N35 G38 Q41 M72 M75 A76 F94 M110 C207 T210 BindingDB: Ki=1.2nM,IC50=2.8nM
External links
PDB RCSB:4mdd, PDBe:4mdd, PDBj:4mdd
PDBsum4mdd
PubMed
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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