Structure of PDB 4mcw Chain A

Receptor sequence
>4mcwA (length=361) Species: 123214 (Persephonella marina EX-H1) [Search protein sequence]
DPERKLKILLDYSSKIANEKDLRNVLLFLTDLAKEIMEADRASIFLYDDQ
KKTLWTIVAHGVDRIEIDADKGIAGYVFRTGEILNIPDAYKDPRFDRDID
KRTGYRTRTILAVPLFDRKQNIIGVFQVINKLTNSVFTEEDIELLRHISL
YASSTIENAILYEKLKKAHEDVIYRLSHATKFKDPETQNHIIRVGLYAEI
LAREAGLDEEDVELVKLAAPMHDIGKVGIPDRVLLKPGKLNDEEWEIMKK
HTIYGYEILKGGDSRLLQIAADIAIEHHERWDGTGYPFGKKGEEISIYGR
MTSISDVFDALTSDRPYKKAWDMDRTVRFFKEQKGKHFDPFLTDIFLKNI
DQMFSIKRELR
3D structure
PDB4mcw Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre.
ChainA
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D222 H250 H276 H277 D223 H251 H277 H278
BS02 FE A E185 D222 E186 D223
BS03 FE A E185 H189 H221 D305 E186 H190 H222 D306
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:4mcw, PDBe:4mcw, PDBj:4mcw
PDBsum4mcw
PubMed24176013
UniProtC0QQ26

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