Structure of PDB 4mc3 Chain A

Receptor sequence
>4mc3A (length=287) Species: 452652 (Kitasatospora setae KM-6054) [Search protein sequence]
FEIPDFYVPFPLECNPHLEEASRAMWEWIDANGLAPTERARDRMRRTGAD
LSGAYVWPRADLDTLTIGLKWIALTFRIDDQILPARMTAIDELRGTLHGL
SPTARALGALWQETALGRPATWCDAFIGHFEAFLQTYTTEAGLNAHGAGL
RLDDYLDRRMYSVGMPWLWDLDELRLPIFLPGSVRTCGPMNKLRRAGALH
IALVNDVFSVYQHNAVTIIREAQGCSLQEAVDQVAVLVEAQLHTVLQARQ
ELLEELDRQALPSRAREAAVDYAANVAANLSGQLVWH
3D structure
PDB4mc3 Hedycaryol synthase in complex with nerolidol reveals terpene cyclase mechanism.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T78 F79 D82 N160 R175 S178 N221 S225 W309 H310
Catalytic site (residue number reindexed from 1) T75 F76 D79 N144 R159 S162 N205 S209 W286 H287
Enzyme Commision number 4.2.3.187: (2Z,6E)-hedycaryol synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 28U A S55 V179 S52 V163
Gene Ontology
Molecular Function
GO:0010333 terpene synthase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4mc3, PDBe:4mc3, PDBj:4mc3
PDBsum4mc3
PubMed24399794
UniProtE4MYY0|HCS_KITSK (2Z,6E)-hedycaryol synthase (Gene Name=KSE_00200t)

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