Structure of PDB 4mao Chain A

Receptor sequence
>4maoA (length=298) Species: 10090 (Mus musculus) [Search protein sequence]
SIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEI
EILLRYGQHPNIITLKDVYDDGKYVYVVMELMKGGELLDKILRQKFFSER
EASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGF
AKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTG
YTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDP
HQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNR
3D structure
PDB4mao Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D539 K541 N544 D561 T581
Catalytic site (residue number reindexed from 1) D125 K127 N130 D147 T167
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 28D A I428 V430 C436 A449 K451 I477 M493 E494 M496 N544 L546 C560 D561 I14 V16 C22 A35 K37 I63 M79 E80 M82 N130 L132 C146 D147 PDBbind-CN: -logKd/Ki=7.33,IC50=47nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4mao, PDBe:4mao, PDBj:4mao
PDBsum4mao
PubMed25153195
UniProtP18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 (Gene Name=Rps6ka3)

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