Structure of PDB 4ma0 Chain A

Receptor sequence
>4ma0A (length=366) Species: 177416 (Francisella tularensis subsp. tularensis SCHU S4) [Search protein sequence]
MKIGIIGAGQLARMLSLAGTPLGLEFHCLGKNGDCAEEVVKTVTDIELTK
VNDVVAWAKQFDVITFENENISHELIKAINHEVSVYPSAKAIAISQDRLL
EKSFMQDHGIATAKFVNIDSLAKLQSAVDDHGLPAILKTRRFGYDGKGQF
VIRSQEDITKAWDVLKDAPDGLIYEAFVDFDYEVSQICTADLKGNIAFYP
LARNTHKQGIIVESEAPFENVVLAEKAQQIAKILVKEFAYVGTLAIEFFV
KGDELIVNEIAPRVHNSGHWSIDGAVTSQFENHVRAIAGLILGDTTSRKT
VMLNCIGGMPATKDLAALDRVKIHSYNKEPRKGRKVGHLNLNLNDETDEY
QLLQVKKLIALSEEIA
3D structure
PDB4ma0 The crystal structure of phosphoribosylaminoimidazole carboxylase ATPase subunit of Francisella tularensis subsp. tularensis SCHU S4 in complex with partially hydrolysed ATP
ChainA
Resolution1.982 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y144 G146 E247 E259 N266 S267 K335
Catalytic site (residue number reindexed from 1) Y144 G146 E247 E259 N266 S267 K335
Enzyme Commision number 6.3.4.18: 5-(carboxyamino)imidazole ribonucleotide synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A I136 K138 E175 A176 F177 V178 E183 H206 F249 E259 I136 K138 E175 A176 F177 V178 E183 H206 F249 E259
Gene Ontology
Molecular Function
GO:0004638 phosphoribosylaminoimidazole carboxylase activity
GO:0005524 ATP binding
GO:0016829 lyase activity
GO:0016874 ligase activity
GO:0034028 5-(carboxyamino)imidazole ribonucleotide synthase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4ma0, PDBe:4ma0, PDBj:4ma0
PDBsum4ma0
PubMed
UniProtQ5NGE8

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