Structure of PDB 4m8x Chain A

Receptor sequence

>4m8xA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]

PQITLWQRPFVTVKIAGQLMEALLDTGADDTILEEMSLPGRWTPKVVGGI
GGFMKVRQYDQILVEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF

3D structure

PDB

4m8x GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.

Chain

Resolution

2.05 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D25 T26 G27
Catalytic site (residue number reindexed from 1)	D25 T26 G27
Enzyme Commision number	3.1.26.13: retroviral ribonuclease H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	KGQ	A	D25 G27 D29 G48 G49 I50	D25 G27 D29 G48 G49 I50	PDBbind-CN: -logKd/Ki=10.20,Ki=0.063nM
BS02	KGQ	A	D25 G27 A28 D30 I32 G48 P81	D25 G27 A28 D30 I32 G48 P81	PDBbind-CN: -logKd/Ki=10.20,Ki=0.063nM

Gene Ontology

	Molecular Function
GO:0004190	aspartic-type endopeptidase activity

	Biological Process
GO:0006508	proteolysis

External links