Structure of PDB 4m8t Chain A

Receptor sequence
>4m8tA (length=303) Species: 10090 (Mus musculus) [Search protein sequence]
QLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRD
PTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVMELMKGGELLDKILRQK
FFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRI
CDFGFAKQLRAENGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLY
TMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKM
LHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA
LNR
3D structure
PDB4m8t Covalent docking of large libraries for the discovery of chemical probes.
ChainA
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D539 K541 N544 D561 T581
Catalytic site (residue number reindexed from 1) D130 K132 N135 D152 T172
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RMM A I428 V430 C436 A449 K451 I477 E494 L495 M496 D561 I19 V21 C27 A40 K42 I68 E85 L86 M87 D152 PDBbind-CN: -logKd/Ki=6.43,IC50=0.37uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4m8t, PDBe:4m8t, PDBj:4m8t
PDBsum4m8t
PubMed25344815
UniProtP18654|KS6A3_MOUSE Ribosomal protein S6 kinase alpha-3 (Gene Name=Rps6ka3)

[Back to BioLiP]