Structure of PDB 4m87 Chain A

Receptor sequence
>4m87A (length=257) Species: 272831 (Neisseria meningitidis FAM18) [Search protein sequence]
GFLQGKKILITGMISERSIAYGIAKACREQGAELAFTYVVDKLEERVRKM
AAELDSELVFRCDVASDDEINQVFADLGKHWDGLDGLVHSIGFAPKEALS
GDFLDSISREAFNTAHEISAYSLPALAKAARPMMRGRNSAIVALSYLGAV
RAIPNYNVMGMAKASLEAGIRFTAACLGKEGIRCNGISAGPIKTLAASGI
ADFGKLLGHVAAHNPLRRNVTIEEVGNTAAFLLSDLSSGITGEITYVDGG
YSINALS
3D structure
PDB4m87 Crystal Structure of Enoyl-Acyl Carrier Protein Reductase (FabI) from Neisseria meningitidis in complex with NAD+
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y157 K164
Catalytic site (residue number reindexed from 1) Y156 K163
Enzyme Commision number 1.3.1.9: enoyl-[acyl-carrier-protein] reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD A G13 I15 S19 I20 V40 D64 V65 S91 I92 G93 I119 L145 S146 Y147 K164 A190 P192 I193 T195 A197 G12 I14 S18 I19 V39 D63 V64 S90 I91 G92 I118 L144 S145 Y146 K163 A189 P191 I192 T194 A196
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004318 enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006633 fatty acid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4m87, PDBe:4m87, PDBj:4m87
PDBsum4m87
PubMed
UniProtA1KVU8

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