Structure of PDB 4m7y Chain A

Receptor sequence
>4m7yA (length=266) Species: 196620 (Staphylococcus aureus subsp. aureus MW2) [Search protein sequence]
MKVGIDAGGTLIKIVQEQDNQRTFKTELTKNIDQVVEWLNQQQIEKLCLT
GGNAGVIAENINIPAQIFVEFDAASQGLGILLKEQGHDLADYIFANVGTG
TSLHYFDGQSQRRVGGIGTGGGMIQGLGYLLSQITDYKQLTDMAQHGDRN
TIDLKVRHIYKDTEPPIPGDLTAANFGHVLHHLDADFTPSNKLAAVIGVV
GEVVTTMAITVAREFKTENIVYIGSSFHNNALLRKVVEDYTVLRGCKPYY
VENGAFSGAIGALYLE
3D structure
PDB4m7y Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2GH A F71 T99 G100 T101 R113 G116 I117 F71 T99 G100 T101 R113 G116 I117 PDBbind-CN: -logKd/Ki=5.32,IC50=4.8uM
BS02 ADP A G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226 G8 G9 T10 L11 K13 G98 T99 G121 Q125 Y137 S225 S226
BS03 2GH A T172 A173 E202 Y240 T172 A173 E202 Y240 PDBbind-CN: -logKd/Ki=5.32,IC50=4.8uM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m7y, PDBe:4m7y, PDBj:4m7y
PDBsum4m7y
PubMed27759386
UniProtQ8NVG0|COAW_STAAW Type II pantothenate kinase (Gene Name=coaW)

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