Structure of PDB 4m7i Chain A

Receptor sequence
>4m7iA (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
GRYLTDFEPIQCLGRFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMR
EVKALAKLEHPGIVRYFNAWLEKKVYLYIQMQLCRKENLKDWMNGRCTIE
ERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFG
LVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTD
VRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
3D structure
PDB4m7i Discovery of 5-{4-fluoro-1-[(6-methyl-2-pyridinyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2656157), a Potent and Selective PERK Inhibitor Selected for Preclinical Development
ChainA
Resolution2.34 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D936 K938 N941 D954 T986
Catalytic site (residue number reindexed from 1) D130 K132 N135 D148 T154
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 27D A V606 A619 L642 V651 Y653 M887 Q888 L889 C890 F943 D954 F955 V19 A32 L55 V64 Y66 M81 Q82 L83 C84 F137 D148 F149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4m7i, PDBe:4m7i, PDBj:4m7i
PDBsum4m7i
PubMed
UniProtQ9NZJ5|E2AK3_HUMAN Eukaryotic translation initiation factor 2-alpha kinase 3 (Gene Name=EIF2AK3)

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