Structure of PDB 4m5p Chain A

Receptor sequence
>4m5pA (length=404) Species: 322104 (Scheffersomyces stipitis CBS 6054) [Search protein sequence]
SSVKISPLKDSEAFQSIKVGNNTLQTKIVYPPTTRFRALEDHTPSDLQLQ
YYGDRSTFPGTLLITEATFVSPQASGWEGAAPGIWTDKHAKAWKVITDKV
HANGSFVSTQLCFLGRVADPAVMKTRGLNPVSASATYESDAAKEAAEAVG
NPVRALTTQEVKDLVYEAYTNAAQKAMDAGFDYIELHAAHGYLLDQFLQP
CTNQRTDEYGGSIENRARLILELIDHLSTIVGADKIGIRISPWATFQNMK
AHKDTVHPLTTFSYLVHELQQRADKGQGIAYISVVEPRVSGNVDVSEEDQ
AGDNEFVSKIWKGVILKAGNYSYDAPEFKTLKEDIADKRTLVGFSRYFTS
NPNLVWKLRDGIDLVPYDRNTFYSDNNYGYNTFSMDSEEVDKELEIKRVP
SAIE
3D structure
PDB4m5p Residues Controlling Facial Selectivity in an Alkene Reductase and Semirational Alterations to Create Stereocomplementary Variants.
ChainA
Resolution1.503 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T35 H188 H191 Y193 R240 Q248
Catalytic site (residue number reindexed from 1) T34 H187 H190 Y192 R239 Q247
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A P33 T34 T35 A68 Q111 H188 R240 N293 G320 N321 F345 S346 R347 F373 Y374 P32 T33 T34 A67 Q110 H187 R239 N292 G319 N320 F344 S345 R346 F372 Y373
BS02 23W A T35 W78 H188 Y193 G292 N293 T34 W77 H187 Y192 G291 N292
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003959 NADPH dehydrogenase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:4m5p, PDBe:4m5p, PDBj:4m5p
PDBsum4m5p
PubMed25068071
UniProtA3LT82

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