Structure of PDB 4m4v Chain A

Receptor sequence
>4m4vA (length=385) Species: 330879 (Aspergillus fumigatus Af293) [Search protein sequence]
NDPAKSAAPYHDEFPLFRSANMASPDKLSTGIGFHSFRIPAVVRTTTGRI
LAFAEGRRHTNQDFGDINLVYKRTKTTANNGASPSDWEPLREVVGSGAGT
WGNPTPVVDDDNTIYLFLSWNGATYSQNGKDVLPDGTVTKKIDSTWEGRL
HLYLTESRDDGNTWSKPVDLTKELTPDGWAWDAVGPGNGIRLTTGELVIP
AMGRNIIGRGAPGNRTWSVQRLSGAGAEGTIVQTPDGKLYRNDRPSQKGY
RMVARGTLEGFGAFAPDAGLPDPACQGSVLRYNSDAPARTIFLNSASGTS
RRAMRVRISYDADAKKFNYGRKLEDAKVSGAGHEGGYSSMTKTGDYKIGA
LVESDFFNDGTGKNSYRAIIWRRFNLSWILNGPNN
3D structure
PDB4m4v Active site mutants of a fungal KDNase
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q83 E249
Catalytic site (residue number reindexed from 1) Q62 E228
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAN A R59 D84 Q148 W202 E249 R265 R322 Y358 R38 D63 Q127 W181 E228 R244 R301 Y337
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:4m4v, PDBe:4m4v, PDBj:4m4v
PDBsum4m4v
PubMed
UniProtQ4WQS0|SIA_ASPFU Exo-alpha-sialidase (Gene Name=AFUA_4G13800)

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