Structure of PDB 4m3b Chain A

Receptor sequence
>4m3bA (length=185) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
RELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLT
LLDRVVNQADMALQTLAEDRENMWRTGINVFFETFGSHKAVTRAGQAARA
TSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMN
ERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGE
3D structure
PDB4m3b Ligand Efficiency Driven Design of New Inhibitors of Mycobacterium tuberculosis Transcriptional Repressor EthR Using Fragment Growing, Merging, and Linking Approaches.
ChainA
Resolution2.001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 2B2 A M102 W103 G106 I107 F110 W138 Y148 T149 N176 N179 E180 W207 M73 W74 G77 I78 F81 W109 Y119 T120 N147 N150 E151 W178 MOAD: ic50=0.4uM
PDBbind-CN: -logKd/Ki=6.40,IC50=0.40uM
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4m3b, PDBe:4m3b, PDBj:4m3b
PDBsum4m3b
PubMed24818704
UniProtP9WMC1|ETHR_MYCTU HTH-type transcriptional regulator EthR (Gene Name=ethR)

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