Structure of PDB 4m38 Chain A

Receptor sequence
>4m38A (length=334) [Search protein sequence]
DAFVNRIDRNIPVPARLRHTPVSLIEAVNDFHYAMMNDEERNNFYYEVLK
KHVTPETGVLEIGAGSGLLSLMAAKLGAKWVVAVEGSEELAKLARENIRA
NNMEHQVKVLHMMSTELKSKHLPEPPDVLLSEIFGTMMLGESALDYVVDV
RNRLLKPTTKIIPQFGTQYAVPIECDALHRISSVSGWRDLDLKHMMTLQD
TVSIVFAKHYGIRMNSVNFRRLSDPIELFRVDFSSSNRNDIPRRKHFDVV
AKESGTAHAMLFYWKVTDDEFVMSTDPEDTVNNFPRDMQWGQALQLLDAS
NGPLPTPVVFTEGKNYNFECNFSGDRVILHMQLC
3D structure
PDB4m38 Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D70 F71 M75 E172 F174 G175 T176 E181 F246 K248 H249 Q329 W330 D30 F31 M35 E132 F134 G135 T136 E141 F206 K208 H209 Q289 W290
BS02 SAH A M75 R81 G103 L109 V124 E125 G126 M153 S154 Y186 M35 R41 G63 L69 V84 E85 G86 M113 S114 Y146
Gene Ontology
Molecular Function
GO:0016274 protein-arginine N-methyltransferase activity
Biological Process
GO:0018216 peptidyl-arginine methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4m38, PDBe:4m38, PDBj:4m38
PDBsum4m38
PubMed24726341
UniProtQ582G4|ANM7_TRYB2 Protein arginine N-methyltransferase 7 (Gene Name=PRMT7)

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