Structure of PDB 4m2a Chain A

Receptor sequence
>4m2aA (length=483) Species: 5664 (Leishmania major) [Search protein sequence]
KSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPV
DSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKT
FLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFD
SEVELMQNQVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQ
ELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKIDFLMEVCRRTESDKK
GGHLARQTVYVKGKDGQPDAEKRVLLLRESAQCPKADMESFQDINKYSFF
NTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETA
MGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDD
RCHGHPPVVDLDSAHYKMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAG
NVLTGTVTIENTDSASAFVIPDGAKLNDTTASP
3D structure
PDB4m2a Catalytic Mechanism and Allosteric Regulation of Udp-Glucose Pyrophosphorylase from Leishmania Major
ChainA
Resolution1.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.9: UTP--glucose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UPG A L81 G83 G84 Q162 G190 H191 N219 G256 G257 E284 N306 N308 F376 K380 L76 G78 G79 Q157 G185 H186 N214 G251 G252 E279 N301 N303 F371 K375
Gene Ontology
Molecular Function
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0006011 UDP-glucose metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m2a, PDBe:4m2a, PDBj:4m2a
PDBsum4m2a
PubMed
UniProtQ4QDU3

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