Structure of PDB 4lzs Chain A

Receptor sequence
>4lzsA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4lzs 4-Acyl pyrroles: mimicking acetylated lysines in histone code reading.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 L46 A P82 F83 V87 L92 N140 I146 P41 F42 V46 L51 N99 I105 MOAD: Kd=16uM
PDBbind-CN: -logKd/Ki=4.80,Kd=16uM
BindingDB: Kd=6800nM
External links
PDB RCSB:4lzs, PDBe:4lzs, PDBj:4lzs
PDBsum4lzs
PubMed24272870
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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