Structure of PDB 4lxd Chain A

Receptor sequence
>4lxdA (length=143) Species: 9606 (Homo sapiens) [Search protein sequence]
RTGYDNREIVMKYIHYKLSQRGYEWDAGSEVVHLTLRQAGDDFSRRYRRD
FAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVES
VNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB4lxd ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 1XV A D100 Y105 M112 E133 N140 W141 G142 R143 Y199 D42 Y47 M54 E75 N82 W83 G84 R85 Y141 PDBbind-CN: -logKd/Ki=7.23,Ki=59nM
BindingDB: Ki=59nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4lxd, PDBe:4lxd, PDBj:4lxd
PDBsum4lxd
PubMed23291630
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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