Structure of PDB 4lwv Chain A

Receptor sequence
>4lwvA (length=85) Species: 8355 (Xenopus laevis) [Search protein sequence]
EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHI
VHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS
3D structure
PDB4lwv Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development.
ChainA
Resolution2.32 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 20W A L50 L53 G54 I57 H69 F82 V89 H92 I95 Y96 L30 L33 G34 I37 H49 F62 V69 H72 I75 Y76 MOAD: ic50=7nM
PDBbind-CN: -logKd/Ki=8.22,IC50=6nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4lwv, PDBe:4lwv, PDBj:4lwv
PDBsum4lwv
PubMed24900784
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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