Structure of PDB 4lwu Chain A

Receptor sequence
>4lwuA (length=85) Species: 8355 (Xenopus laevis) [Search protein sequence]
EKLVQPTPLLLSLLKSAGAQKETFTMKEVLYHLGQYIMAKQLYDEKQQHI
VHCSNDPLGELFGVQEFSVKEHRRIYAMISRNLVS
3D structure
PDB4lwu Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.
ChainA
Resolution1.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 20U A L50 L53 I57 M58 H69 F82 V89 K90 H92 I95 Y96 L30 L33 I37 M38 H49 F62 V69 K70 H72 I75 Y76 MOAD: ic50=0.005uM
PDBbind-CN: -logKd/Ki=8.30,IC50=0.005uM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4lwu, PDBe:4lwu, PDBj:4lwu
PDBsum4lwu
PubMed24997575
UniProtP56273|MDM2_XENLA E3 ubiquitin-protein ligase Mdm2 (Gene Name=mdm2)

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