Structure of PDB 4lw3 Chain A

Receptor sequence
>4lw3A (length=242) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
DGASVHKMALLVPFRDRFEELLQFVPHMTAFLKRQGVAHHIFVLNQVDRF
RFNRASLINVGFQFASDVYDYIAMHDVDLLPLNDNLLYEYPSSLGPLHIA
GPKLHPKYHYDNFVGGILLVRREHFKQMNGMSNQYWGWGLENDEFFVRIR
DAGLQVTRPQNIKTGTNDTFSHIHNRYHRKRDTQKCFNQKEMTRKRDHKT
GLDNVKYKILKVHEMLIDQVPVTILNILLDCDVNKTPWCDCS
3D structure
PDB4lw3 Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D145 D147 W207 E210 N211 T238 H241 H243
Catalytic site (residue number reindexed from 1) D76 D78 W138 E141 N142 T169 H172 H174
Enzyme Commision number 2.4.1.133: xylosylprotein 4-beta-galactosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D147 H241 H243 D78 H172 H174
BS02 GDU A P82 F83 R84 R86 F121 R123 D145 V146 D147 Y177 G185 W207 G208 E210 N211 H241 H243 R250 P13 F14 R15 R17 F52 R54 D76 V77 D78 Y108 G116 W138 G139 E141 N142 H172 H174 R181
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4lw3, PDBe:4lw3, PDBj:4lw3
PDBsum4lw3
PubMed24052259
UniProtQ9VBZ9|B4GT7_DROME Beta-1,4-galactosyltransferase 7 (Gene Name=beta4GalT7)

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