Structure of PDB 4lvt Chain A

Receptor sequence
>4lvtA (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
YDNREIVMKYIHYKLSQRGYEWDASEVVHLTLRQAGDDFSRRYRRDFAEM
SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNRE
MSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGP
3D structure
PDB4lvt ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1XJ A D100 F101 R104 Y105 D108 M112 L134 N140 W141 G142 R143 F195 L198 Y199 D38 F39 R42 Y43 D46 M50 L72 N78 W79 G80 R81 F133 L136 Y137 PDBbind-CN: -logKd/Ki=10.36,Ki=44pM
BindingDB: Ki=<1.000000nM,IC50=<15nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:4lvt, PDBe:4lvt, PDBj:4lvt
PDBsum4lvt
PubMed23291630
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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