Structure of PDB 4luj Chain A

Receptor sequence
>4lujA (length=214) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search protein sequence]
HMPKLMLALDVLDRDRALKIVEDVKDYVDAIKVGYPLVLSTGTEIIKEIK
KLCNKEVIADFKVADIPATNEKIAKITLKYADGIIVHGFVGEDSVKAVQD
VAKKLNKKVIMVTEMSHPGAVQFLQPIADKLSEMAKKLKVDAIVAPSTRP
ERLKEIKEIAELPVITPGVGAQGGKIEDILNILDENDYVIVGRAIYQSQN
PKEEAKKYKEMLNK
3D structure
PDB4luj Crystal structure of Orotidine 5'-monophosphate decarboxylase from methanocaldococcus jannaschii complexed with inhibitor BMP
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMP A D29 K81 M134 S135 P186 Q191 G211 R212 D10 K62 M115 S116 P167 Q172 G192 R193
BS02 BMP A D84 I85 T88 D65 I66 T69
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4luj, PDBe:4luj, PDBj:4luj
PDBsum4luj
PubMed
UniProtQ57700|PYRF_METJA Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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